Metabolism Ketamine is metabolized via N-dealkylation to the Energetic metabolite norketamine largely by CYP2B6 and CYP3A4 also to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation of your cyclohexone ring to form hydroxynorketamine compounds by way of CYP-dependent pathways, which are conjugated with glucuronic acid and sub